Although the presently preferred embodiment of the invention contemplates the usage of the phosphodiesterase inhibitor sildenafil citrate as the popular active for the methods set forth herein in the remedy and/or prevention of EIPH, it is particularly contemplated that other phosphodiesterase inhibitors are inside the scope of the invention. In particular, the invention relates to strategies and devices for nebulization therapy in horses for the remedy and prevention of respiratory circumstances including Exercise-Induced Pulmonary Hemorrhage (EIPH) and related pulmonary sequella in the horse. The foregoing and other objects, options and advantages of the current invention ought to turn into apparent to these of talent in the artwork in the following description when taken at the side of the accompanying drawings and through follow of the invention. Accordingly, there still exists a need in the art for such methods. In the embodiment proven, in FIG. 1, the system 10 and attachment means 20 are proven attached to the head 30 of the subject equine and lying beneath a typical equine halter 60. Thus, one in all skill in the artwork can respect that the machine 10 and attachment means 20 could be attached and used independent of however in conjunction with halters, bridles or different equine head gear.
Within the embodiment proven in FIG. 1, the attachment means 20 itself is a halter-type or halter-like apparatus constructed of nylon or leather with adjustable straps for securing to the top 30 of the subject equine and is separate from halter 60. As set forth more filly below, the attachment means 20 for the device 10 will be separate from halter 60 or integrated therein. The machine 10 or equine nasal cannula might be designed to conform to or change into an integral a part of harness and/or bridle or other halter-type tools usually associated with the training and racing of equine athletes. Thus, the present invention offers an inhalation therapy regimen administered through, e.g., a non-invasive equine nasal cannula machine as additionally offered by the invention. In a presently most popular embodiment, the invention gives a way for the therapy or prevention of EIPH, wherein the composition for inhalant therapy is a mixture comprised of sildenafil citrate or its congeners (e.g., metabolites, isomers, salts or different active derivatives of sildenafil citrate) utilizing air because the delivery car to hold the inhalant into the equine mammal. In a single embodiment, the therapy regimen consists of the introduction of a composition comprised of sildenafil citrate or congeners of sildenafil citrate with or with out potentiating brokers delivered to the topic equine by way of the attendant inhalation therapy system in a non-invasive method that is conducive to the care and comfort of the equine mammal under therapy.
The device 10 is held in place by attachment means 20 such that the distal ends 16, 18 of elongated delivery tubes 12, 14 (cannulas) are positioned adjacent the exterior openings 32, 34 of the topic equine’s nasal cavity (adjacent the nares) so as to successfully deliver the composition selected for inhalation at the suitable site. Within the presently most well-liked embodiment, the machine 10 of the invention (the equine nasal cannula) is comprised of a nylon attachment means 20 (just like a halter) that is configured to adapt to the contours of the equine skull 30 in such a way as to effectively place and hold the distal ends 16, 18 of the elongated supply tubes 12, 14 in a desired place for the administration of a therapeutic inhalant while minimizing the requirements for specialised animal restraint and/or restriction of movement. In a single embodiment, padded extrusions (not shown) are supplied at the distal ends 16, 18 (nasal end) of the elongated tubes 12, 14 (cannulas) to prevent harm or irritation which will happen from rubbing the nostrils or the internal linings (mucosa) of the nostrils.
Thus, the dimensional and different characteristics proven in FIGS. FIG. 5 is a perspective view of 1 embodiment of the nebulization apparatus and air provide for supply of a desired therapeutic agent via the machine of FIGS. FIG. 3 is a perspective view of one embodiment of the nasal cannula portion of the gadget of the invention. FIG. 7 is a shade digital photograph exhibiting a left frontal view of 1 embodiment of the system of the invention. It’s an object of the invention to offer an inhalation therapy regimen and system for the treatment and/or prevention of EIPH comprising the inhalation of a therapeutic amount of sildenafil citrate and/or the metabolites of sildenafil citrate alone or together with different compounds. Studied for its immune well being benefits, N-Acetyl-L-Cysteine 98% nutritional defends against insults from foreign compounds. Generally speaking, simple natural compounds formed by the replacement of a hydrogen atom of hydrogen sulfide by an aliphatic, aromatic or heterocyclic radical are referred to as “thiols,” e.g. methanethiol; whereas, polyfunctional compounds so formed are often described with the prefix “mercapto,” comparable to mercaptoacetic acid.
